pulmonary edema and covid vaccine

An official website of the United States government. Adult Respiratory Distress Syndrome. Acad. (2019). North America 33 (4), 869889. Epub 2022 Oct 17. (2020a). Am. 346, 16311636. Dis. 308 (11), L1178L1188. Infect. Open Forum Infect. In March 2020, the World Health Organization (WHO) declared Coronavirus Disease 2019 (COVID-19) a pandemic, therefore the efforts of scientists around the world are focused on finding the right treatment and vaccine for the novel disease. Epub 2020 Jun 20. 275 (2), L414L422. Semin. (2014). (2016). The .gov means its official. The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. Adv. Sci. Ann. 97 (5), 543554. Fondazione Salvatore Maugeri (IRCCS), Italy. 11, 1708. doi:10.3389/fimmu.2020.01708, Thanh Le, T., Andreadakis, Z., Kumar, A., Gmez Romn, R., Tollefsen, S., Saville, M., et al. The general regulation approaches of AFC. Front. Here, we provide a perspective on abnormal lung humoral metabolism of pulmonary edema in COVID-19 patients, review the mechanisms by which pulmonary edema may be induced in COVID-19 patients, and propose putative drug targets that may be of use in treating COVID-19. Xue-Bi-Jing injection is also widely applicated in treating COVID-19 patients and by adding it based on the routine anti-infective therapy, the 28-day mortality of patients with severe pneumonia could be reduced by 8.8%, greatly improving pneumonia severity index (from 93.18 23.17 to 52.18 30.53) (Ma et al., 2020b). Ijerph 17 (15), 5320. doi:10.3390/ijerph17155320, Kunzelmann, K., Beesley, A. H., King, N. J., Karupiah, G., Young, J. doi:10.1074/jbc.M100322200, Udugama, B., Kadhiresan, P., Kozlowski, H. N., Malekjahani, A., Osborne, M., Li, V. Y. C., et al. There are also several natural compounds which were previously shown to have positive effects on the lung edema-associated targets described in this paper (Zhou et al., 2006; Ho et al., 2007; Ji et al., 2014; Wang et al., 2015; Qu, 2019; Fan et al., 2020; Lung et al., 2020). doi:10.1152/ajplung.00244.2017, Looney, M. R., Sartori, C., Chakraborty, S., James, P. F., Lingrel, J. Sci. As such, TRPV4 inhibition likely has protective and beneficial effect on mucus clearance and pulmonary edema. doi:10.1152/ajplung.00285.2017, Beigel, J. H., Tomashek, K. M., Dodd, L. E., Mehta, A. K., Zingman, B. S., Kalil, A. C., et al. Adipose-derived Exosomes Protect the Pulmonary Endothelial Barrier in Ventilator-Induced Lung Injury by Inhibiting the TRPV4/Ca2+ Signaling Pathway. TRPA1 distributes on C-fibers throughout the respiratory system (De Logu et al., 2016). doi:10.1136/gutjnl-2020-320953, Zhang, J.-L., Zhuo, X.-J., Lin, J., Luo, L.-C., Ying, W.-Y., Xie, X., et al. Jiangsu Qing Lan Project for Young Academic Leaders of China. CDC/FDA announce pause in use of Janssen COVID-19 Vaccine after identification of 6 cases of CVST with thrombocytopenia. Lancet Respir. JAMA 249 (2), 237241. Although NT-proBNP had an AUC of 0.89 in our patients with acute pulmonary edema, the study that reported an AUC of 0.96 did not include acute pulmonary edema or acute heart failure , and they excluded patients with eGFR < 60 mL/min/1.73 m 2, a group that constituted nearly half of our patients with hypertensive emergency. Impaired Breakdown of Bradykinin and its Metabolites as a Possible Cause for Pulmonary Edema in COVID-19 Infection. N. Engl. Rhinovirus Upregulates Transient Receptor Potential Channels in a Human Neuronal Cell Line: Implications for Respiratory Virus-Induced Cough Reflex Sensitivity. Care Med. Dexamethasone for the Treatment of Coronavirus Disease (COVID-19): a Review. doi:10.1530/EJE-20-0338, Clapham, D. E., Runnels, L. W., and Strbing, C. (2001). (2020). 96 (5), 25142519. Since the inhibition of ENaC induces pulmonary edema formation, targeting ENaC is rational in order to enhance fluid clearance from the alveoli. N.Y. Acad. Phytomedicine 85, 153315. doi:10.1016/j.phymed.2020.153315, Zhou, Z., Wang, S.-Q., Liu, Y., and Miao, A.-D. (2006). doi:10.1056/NEJMoa2028836, Tang, Y., Liu, J., Zhang, D., Xu, Z., Ji, J., and Wen, C. (2020). 4 (159), 159ra148. Evidences for TRPs as medium of lung injury are emerging from studies on various inhalational chemical threats (Achanta and Jordt, 2020). ACS Nano 14 (4), 38223835. According to previous studies, activation of AT1 receptor inhibits AFC by down-regulating cAMP and dysregulating ENaC expression, leading to Ang II-dependent pulmonary edema and alveolar filling increase (Deng et al., 2012). Recently, several companies came out with vaccines against COVID-19 which have been approved for use. [Effect of Astragali Radix in Improving Early Renal Damage in Metabolic Syndrome Rats through ACE2/Mas Pathway]. (2020b). 2020. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). SARS-CoV-2 may act in a similar way. Inhibiting these TRPs may benefit the treatment of pulmonary edema. medRxiv.doi:10.1101/2020.05.20.20107607, Hu, K., Guan, W.-j., Bi, Y., Zhang, W., Li, L., Zhang, B., et al. doi:10.1007/s00134-007-0962-y, Niu, F., Xu, X., Zhang, R., Sun, L., Gan, N., and Wang, A. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). 80 (4), 394400. Before doi:10.1016/j.bbamem.2012.02.025, Bartoszewski, R., Matalon, S., and Collawn, J. F. (2017). Res. doi:10.1101/2020.02.13.20022673, Alvarez, D. F., King, J. J. Physiology-Lung Cell Mol. (1997). doi:10.1111/joim.13091, Passi, A., Negrini, D., Albertini, R., de Luca, G., and Miserocchi, G. (1998). doi:10.1007/s00018-007-6228-6, Itani, O. J. Biol. doi:10.1126/scitranslmed.3004276, Towne, J. E., Krane, C. M., Bachurski, C. J., and Menon, A. G. (2001). *Correspondence: Hongyue Ma, hongyuema@njutcm.edu.cn; Edyta Marcon, edyta.marcon@utoronto.ca; Jing Zhou, zhoujing_nj@126.com, Abnormal Lung Humoral Metabolism in COVID-19, Conventional Treatment of Pulmonary Edema in COVID-19 Patients, Putative Drug Targets for Pulmonary Edema in COVID-19 Patients, Natural Compounds and Traditional Chinese Medicines for the Treatment of Pulmonary Edema in COVID-19, https://doi.org/10.3389/fphar.2021.664349, https://www.frontiersin.org/articles/10.3389/fphar.2021.664349/full#supplementary-material, http://www.nhc.gov.cn/yzygj/s7653p/202003/46c9294a7dfe4cef80dc7f5912eb1989.shtml. Aldosterone-induced Sgk1 Relieves Dot1a-Af9-Mediated Transcriptional Repression of Epithelial Na+ Channel . J. Clin. Breathtaking TRP Channels: TRPA1 and TRPV1 in Airway Chemosensation and Reflex Control. Nature 590, 635641. doi:10.7150/ijbs.45538, Yang, Y., Shen, C., Li, J., Yuan, J., Yang, M., Wang, F., et al. Most of the published data about this association come from case reports and series. 3 (1), 237261. Ion channels, AQPs, RAS, bradykinin and hyaluronic acid are factors influencing the pulmonary edema. CFTR inhibitors, like glibenclamide and CFTRinh-172 inhibitor, distinctly reduced absorptive alveolar fluid transport (Solymosi et al., 2013). Large Conductance Ca2+-Activated K+ Channels Sense Acute Changes in Oxygen Tension in Alveolar Epithelial Cells. (2020). (2009). It has been shown that the incidence and severity of COVID-19 are closely related to abnormal metabolism of inorganic salts. doi:10.1161/01.RES.0000247065.11756.19, Andr, E., Gatti, R., Trevisani, M., Preti, D., Baraldi, P., Patacchini, R., et al. FIGURE 3. COVID-19 Treatment and Diagnosis Guideline (7th version, trial) [Online]. J. Physiol. Remdesivir for the Treatment of Covid-19 - Final Report. 291 (6), L1207L1219. Rev. doi:10.1152/ajplung.00290.2014, Ji, G., Chen, R., and Zheng, J. Crit. (1999). A., Auerbach, S. D., Husted, R. F., Volk, K. A., Ageloff, S., Knepper, M. A., et al. (2001). doi:10.1007/s11427-020-1637-5, Xu, Y.-H., Dong, J.-H., An, W.-M., Lv, X.-Y., Yin, X.-P., Zhang, J.-Z., et al. The toad venom injection can significantly improve the pulmonary function of COVID-19 patients by regulating PaO2/FiO2 and ROX index and thus alleviate pulmonary edema. TRPV1, expressed in C-fibers of the vagus nerves innervating airways (Cui et al., 2016), has been considered to play a key role in cough reflex and increased airway sensitivity caused by various diseases (Andr et al., 2009; Couto et al., 2013). Therefore, the S protein determines the host cell of the virus, regulates the viral attachment and fusion with the host cell membrane, and promotes cellular invasion. Amiloride was shown to induce the reduction of ACE2 expression in bronchial and alveolar epithelial cells (Adil et al., 2020) and can counteract the low cytosolic pH which has been observed in COVID-19 patients by acting on Na+/H+ exchanger (Cure and Cumhur Cure, 2020). J. Respir. (2020). doi:10.1002/jmv.25761, Luo, X., Ni, X., Lin, J., Zhang, Y., Wu, L., Huang, D., et al. Authors Med. 2020 Mar 23:3558887. doi: 10.2139/ssrn.3558887. J. Physiol. 50 (4), 113. (2021). Pediatr. We identified pulmonary edema, pleural effusion, and pericardial effusion. Consequently, drugs that can normalize humoral metabolism should be clinically evaluated for their use in the treatment of COVID-19 patients (Table 1). Med. medRxiv. Mol. 54 (3), 678811. doi:10.1101/2020.03.31.20038935, Yang, R., Liu, H., Bai, C., Wang, Y., Zhang, X., Guo, R., et al. ACE2 is most abundantly expressed in human vascular endothelial cells as well as alveolar and intestinal epithelial cells. Transient Receptor Potential Channels in Pulmonary Chemical Injuries and as Countermeasure Targets. doi:10.1001/jama.2020.12839, Wittekindt, O. H., and Dietl, P. (2019). However, among all current treatments mentioned above, little attention has been paid to the abnormal humoral metabolism and pulmonary edema, which is a key factor threatening patients lives. Among all vaccine recipients, 66.6% reported at least one systemic reaction in the 7 days after vaccination. Hyponatremia (low blood sodium concentration) as well as low concentrations of potassium and calcium in the blood serum are also associated with COVID-19 (Lippi et al., 2020). Summary of potential TCM formulae against COVID-19. Sci. doi:10.1146/annurev.pa.17.040177.001053, Fronius, M. (2013). doi:10.1101/2020.03.02.20029975, Yin, J., Hoffmann, J., Kaestle, S. M., Neye, N., Wang, L., Baeurle, J., et al. Circuits between Infected Macrophages and T Cells in SARS-CoV-2 Pneumonia. IL6 monoclonal antibody or tocilizumab was thought to work by interrupting inflammatory storm after the infection, but the latest clinical study published in NEJM showed that Tocilizumab was not effective in preventing intubation or death in mild hospitalized COVID-19 patients (Stone et al., 2020). (2020). IFN will continually induce inflammatory cytokines released by alveolar macrophages, promoting the activation of T cells and forming a positive feedback loop that drives persistent alveolar inflammation (Grant et al., 2021). Intensive Care Med. Currently, these symptoms are the primary consequences of pulmonary virus infection. Chloride Transport-Driven Alveolar Fluid Secretion Is a Major Contributor to Cardiogenic Lung Edema. Qing-Fei-Pai-Du Decoction, which is officially recommended for the treatment of COVID-19 patients as mentioned in the guideline issued by NHC (Trial 7th edition) (PRC, 2020), has an effective rate higher than 90% (2020) and can mediate the inflammatory storm induced by COVID-19 (Yang et al., 2020b), regulate the innate immune, cytokine activities (IL-17, NF-B, TNF etc. Cytokine Storm in COVID-19: The Current Evidence and Treatment Strategies. Elife 9, e59177. (2020). - Eur. The fluid transudes into and accumulates in the interstitium of lungs and finally alveolars from lung capillary, leading to severe disorder of pulmonary ventilation and gas exchange (Staub, 1974). Rev. doi:10.1016/j.molimm.2018.09.003, Solymosi, E. A., Kaestle-Gembardt, S. M., Vadasz, I., Wang, L., Neye, N., Chupin, C. J. The available adenoviral vaccines appear to stimulate autoantibodies to platelet factor 4 (PF4), which . 8 (5), 475481. 8 (8), 807815. Purpose To investigate pulmonary vascular abnormalities at CT pulmonary angiography (CT-PE) in patients with coronavirus disease 2019 (COVID-19) pneumonia. FIGURE 1. Am. A. H. (2020). includes glycoproteins, membranes and nucleic acids. Matrix Proteinases in Lung Biology. Here, we summarized several natural compounds and TCM formulas which are very likely to be potential drugs or have already shown predominant efficacy of COVID-19 patients. Res. [Med. medRxiv. As Gabazza et al., (2004) reported, lung fibrosis is linked to decreased mRNA and protein expression of AQP-5 in the lung. eCollection 2023. Cause of COVID-19 pulmonary edema. Further, ARDS is sometimes initially diagnosed as pneumonia or pulmonary edema (fluid in the lungs from heart disease). Presenting Characteristics, Comorbidities, and Outcomes Among 5700 Patients Hospitalized with COVID-19 in the New York City Area. As RAS plays an important role in PFC and AFC, astragaloside IV from Astragalus propinquus is able to protect kidney and respiratory by activating the ACE2-Ang-(17)-Mas pathway in RAS and improving ACE2, Ang-(17), Mas level (Wang et l., 2015; Qu, 2019). (2006) reported that the cryptotanshinone in Salvia miltiorrhiz can inhibit the synthesis of cGMP and NO in vein endothelial cells, activate NO/cGMP pathway and improve the blood circulation. Currently, many clinical trials are in progress to test coronavirus treatment, including new drugs and drug repurposing or repositioning. doi:10.1111/j.1440-1827.2004.01754.x, Garvin, M. R., Alvarez, C., Miller, J. I., Prates, E. T., Walker, A. M., Amos, B. K., et al. Influenza Virus Infection Alters Ion Channel Function of Airway and Alveolar Cells: Mechanisms and Physiological Sequelae.

Celtic Honey Liqueur Australia, What Actress Lived In The Haunted Museum In 1971, Articles P